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Manual and automated solvent-free mini-ball mill (MBM) matrix-assisted laser desorption/ionization (MALDI) analysis of mixtures of beta-amyloid peptides (1-11), (33 …
Planetary Ball Mills have been proven their applicability as reactors for organic syntheses from different points of view. Performance of chemical reactions in the solid state without a solvent takes advantage of the high mixing efficiency of Ball Mills and the continuous particle refinement resulting in surfaces with high activity.
Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF–Al 2 O 3 differ in water content. The ...
This study investigates the effect of using ethanol as the process control agent during the wet ball milling of niobium (Nb). Dried nanocrystal Nb powders, of high purity, with particle sizes ...
The solvent-free synthesis of core-functionalised naphthalene diimide (c-NDI) residues in a vibratory ball mill is reported. Twenty-one naphthalene diimide-based products were produced by using Suzuki, Sonogashira and Buchwald-Hartwig palladium coupling reactions, including dimeric diimide products that are constituents in functioning …
Mechanochemical ball milling has emerged as a viable choice in chemical synthesis because of its several advantages, including solvent-free synthesis, increased pace, scalability, the ability to adjust reaction parameters, unusual …
DOI: 10.1016/J.JASMS.2007.04.017 Corpus ID: 12017485; Solvent-free MALDI-MS for the analysis of β-amyloid peptides via the mini-ball mill approach: Qualitative and quantitative advances
The optimum conditions maintained to operate ball mill is 450 rpm with five balls (10 mm) for 3 min [57]. Download : Download full-size image; Ze et al. demonstrated one-pot and solvent-free synthesis of 3,5-diphenyl-1H-pyrazoles in an excellent yield under mechanochemical ball-milling conditions using sodium persulfate as the oxidant [60].
Amongst all the methods that can be employed for the mechano-chemical processing of cellulose, ball milling is an emerging technique, which allows avoiding organic solvents. Being easy to use, fast, economical and environmentally friendly, this technique has recently acquired growing interest in chemistry.
The solvent-free method was used to analyze high MW polymers giving at least equal quality mass spectra up to 100 kDa . The solvent-free mortar and pestle …
Ball Mills are systems developed for refining particles or desagglomeration of aggregated species. This capability makes ball mills a useful tool for up- and down-stream processes in a range of applications …
I. Solvent-free based on the mini-ball mill (MBM) method A general solvent-free protocol was used [ 4 ]. Mixing of the analyte and matrix powder was performed …
The ball-mill-based mechanochemical activation of metallic copper powder facilitates solvent-free alkyne-azide click reactions (CuAAC). All parameters that affect reaction rate (i.e.,...
Manual and automated solvent-free mini-ball mill (MBM) matrix-assisted laser desorption/ionization (MALDI) analysis of mixtures of beta-amyloid peptides (1-11), (33-42), (1-42) and...
the ball materials, diameters and ball numbers, may sig-nificantly influence the final yield. Generally, the Φ10 mm balls were proved better than others (entries 5, 7 vs. 6, 8); agate ball as well as stainless steel ball gave better yields than zirconium oxide ball (entries 4, 7 vs. 5). As the grinding bowl volume is fixed in the ball mill
The chemical synthesis without solvents provides neat reaction, good product yields in short reaction time with easy separation, workup, and purification. So, the solvent-less reactions minimize the production of by-products or waste by avoiding the use of conventional volatile organic solvents.
A ball-mill, solvent-free technique was applied and optimization of the reaction circumstances for this particular reaction was studied. Table 3 represents the data obtained from the catalyzed reactions. It is found that MFI27_6 catalyst showed the highest product % yield (91%) in the shortest time (20 min) utilizing 0.25 g of catalyst and 30 ...
A mini ball mill (MBM) solvent-free matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) method allows for the analysis of …
Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF–Al2O3 differ in water content.
A mini ball mill (MBM) solvent-free matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) method allows for the analysis of bacteriorhodopsin (BR), an integral membrane protein that previously presented special analytical problems.
Manual and automated solvent-free mini-ball mill (MBM) matrix-assisted laser desorption/ionization (MALDI) analysis of mixtures of β -amyloid peptides ( 1–11 ), ( 33–42 ), ( 1–42) and non- β -amyloid component of Alzheimer's disease peptide yielded interpretable spectra for all of the peptides present regardless of their relative amounts in …
ABSTRACT. An easy, solvent-free method for the synthesis of 1- (4-chlorophenyl)pyrazolidin-3-one has been achieved by grinding 4-chlorophenyl hydrazine and methyl acrylate in the presence of base in a ball mill. A systematic investigation of the reaction has been made in order to study the various factors affecting the reaction.
An efficient, low sample load mini-ball mill (MBM) sample preparation procedure was developed for solvent-free MALDI analysis of peptides and proteins. Picomole sample …
An efficient, low sample load mini-ball mill (MBM) sample preparation procedure was developed for solvent-free MALDI analysis of peptides and proteins. Picomole sample amounts can be handled conveniently, with 30 s grinding times being sufficient. Matrix purity and molar analyte/matrix ratios are no …
Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball …
Manual and automated solvent-free mini-ball mill (MBM) matrix-assisted laser desorption/ionization (MALDI) analysis of mixtures of β-amyloid peptides (1–11), (33–42), (1–42) and non-β-amyloid component of Alzheimer's disease peptide yielded interpretable spectra for all of the peptides present regardless of their relative amounts in the samples.
Manual and automated solvent-free mini-ball mill (MBM) matrix-assisted laser desorption/ ionization (MALDI) analysis of mixtures of -amyloid peptides (1-11), (33-42), (1-42) and non- -amyloid component of Alzheimer's disease peptide yielded interpretable spectra for all of the peptides present regardless of their relative amounts in the samples.
Magnetic carbonaceous adsorbents were synthesized by ball-milling biochar (BC) or activated carbon (AC) with Fe 3 O 4 nanoparticles, and their capacities to sorb methylene blue () from water were evaluated and compared. Ball milling with magnetite not only improved the surface properties of the carbonaceous adsorbents, especially BC, …
Ball milling is a simple, fast, cost-effective green technology with enormous potential. One of the most interesting applications of this technology in the field of cellulose is the preparation...
Ball Mills are systems developed for refining particles or desagglomeration of aggregated species. This capability makes ball mills a useful tool for up- and down-stream processes in a range of applications in the pharmacy, food technology, chemical industry etc. Reactive Milling
Abstract. An efficient, low sample load mini-ball mill (MBM) sample preparation procedure was developed for solvent-free MALDI analysis of peptides and …
Hence, it can be said that the solvent-free system has the advantages of [145] [146] [147]: (ⅰ) the high concentration of reaction substrate; (ⅱ) fast reaction speed; (ⅲ) small reaction volume;...
In this method, the BBs behave as a mini-ball mill to effectively grind together the analyte, matrix, and cationization agent. The method is fast and effective. Figure 2 shows MALDI mass spectra of the PS 5050 sample prepared by both the mortar and pestle method (top) and our new BB method (bottom).
An efficient, low sample load mini-ball mill (MBM) sample preparation procedure was developed for solvent-free MALDI analysis of peptides and proteins. Picomole sample amounts can be...
An efficient, low sample load mini-ball mill (MBM) sample preparation procedure was developed for solvent-free MALDI analysis of peptides and proteins. Picomole sample amounts can be handled conveniently, with 30 s grinding times being sufficient. Matrix purity and molar analyte/matrix ratios are not as critical as with methods employing solvent.